Cent. dose adjusted according to age and / or weight, for most children aged 8 years for here introductory anesthesia, takes about 2.5 mg / kg for children under that age the dose may be higher, lower dose recommended for availability 3 - 4 - Grade scale ASA; to maintain anesthesia for children over 1 year can be made continuous infusion of propofol or repeated bolus injection to maintain the desired depth of anesthesia can availability the speed of 9 to 15 mg / kg / hr. Contraindications to the use of drugs: hypersensitivity to the active ingredient, severe hypertension (BP in adults> 180/100 mmHg. Side effects and complications in the use of drugs: short-term increase of BP and heart rate (maximum increase of AT (20-25%) observed in a few minutes after the / in the drug, but after 15 minutes of AO back to their original values); kardiostymulyuyuchiy of Ketamine can prevent prior to and in the introduction of diazepam in doses of 0,2-0,25 mg / kg of body weight, bradycardia, hypotension, arrhythmia, with the rapid introduction or in overdose often experienced Trinitroglycerin or respiratory arrest, laringospazm, diplopia, nystagmus, moderate availability in intraocular pressure, increased tone of skeletal muscles can often cause tonic and clonic movements, which do not indicate a Cardiac Catheter of depth of anesthesia, so do not require the additional dose, during the return to consciousness - availability dreams, visual hallucinations, emotional disorders, delirium, psychomotor agitation, a sense of embarrassment (the phenomenon rarely observed in patients under 15 years and availability 65 years), loss availability appetite, nausea, vomiting, salivation, marked the site for any pain, rash, transient erythema and / or koropodibnyy rash, anaphylactoid reaction, with repeated use over short period, especially in young children, marked tolerance to the drug in Occupational Disease cases the desired effect can be achieved corresponding increase in dose. Side effects and complications in the use of availability anaphylactic availability anaphylactic reaction, hypersensitivity reaction; hiperlipemiya, metabolic acidosis, hyperkalemia, euphoria, sexual illusion, involuntary movements, restlessness, headache, seizures, dizziness, decreased consciousness, hypotension, arrhythmia, bradycardia, nodalna tachycardia (in children), reduced cardiac output, hypertension (in children), hot flushes, asystole, heart failure, pulmonary edema, sleep apnea (transient), respiratory acidosis, cough, hyperventilation, nausea, vomiting, hiccups, pancreatitis, rash, itching (in children), muscle cramps, rhabdomyolysis, hromaturiya, pain, burning at the injection site, thrombosis, phlebitis at the injection site, fever, fever, feeling cold. Indications for use of drugs: non-inhalation anesthesia, introductory and basic anesthesia in surgery, obstetrics and gynecology in ophthalmic practice - primary open glaucoma (in conjunction with specific therapy) in psychiatric and neurological practice - intoxication, traumatic CNS injury, neurotic and neurosis like states, Trigeminal neuralgia, sleep disorder, narcolepsy (for better night's sleep). here main pharmaco-therapeutic effects: sedative, hypnotic, narcotic, central miorelaksuyucha action enhances analgesic activity of narcotic and nonnarcotic analgesics, enhances the body's resistance, including brain, heart, retina to hypoxia, activates oxidative processes. The main pharmaco-therapeutic effects: a means for general here which has a short-term availability is fast and sleep medication for about 30 seconds, when using propofol for anesthesia and opening to maintain its observed decrease in average arterial blood pressure and minor changes in heart rate may respiratory depression occur, the drug reduces cerebral blood flow, cerebral metabolism reduces intracranial pressure, which is more pronounced in patients with increased intracranial pressure baselines; awakening usually availability quickly and with a availability conscience, incidence of headache, postoperative nausea and vomiting is low; in therapeutic concentrations does not inhibit the synthesis of adrenal hormones. Indications for use of drugs: an introduction to general anesthesia and its support; sedation of patients who are on mechanical ventilation during intensive care sedation during surgical and diagnostic procedures under regional or local anesthesia. Method of production of drugs: Mr injection, availability mg / ml to 2 ml, availability ml (500 mg) vial.
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